Background
Gene editing technology is one of the frontiers of biotechnology. However, the leading technologies cannot control editing outcomes. Current gene editors leave DNA ends that are compatible when they cut DNA allowing random length insertions / deletions and only resulting in infrequent levels of DNA repair.
Tech Overview
Dualase is a new gene editing tool designed to efficiently disrupt or repair target DNA sequences. Dualase is a single-chain, dual-cleaving nuclease cuts DNA at two sites, leaving non-compatible DNA ends for precision disruption & increased frequency of gene correction. This allows targeting of genetic diseases that cannot be targeted by current technologies.
Advantages
- Precise gene disruption with defined length deletions
- Improved gene repair
- High compatibility with delivery vehicles (e.g AAV)
- Improved programmability
- Lower Potential Off Targets