Description of the Invention
Avro Life Science has developed a novel material for transdermal drug delivery of multiple small molecule drugs, across a wide range of therapeutic categories including cardiovascular health, neuroscience, diabetes, consumer health, and more. The TDS (transdermal delivery system) is a drug-in-adhesive patch with a backing film, adhesive layer, and a release liner. The technology centers around the aqueous-based adhesive layer, which consists of at least six major feature components: a naturally occurring polysaccharide, a synthetic polymer, a bioadhesive component, a plasticizer, a keratolytic agent, and the active pharmaceutical ingredient (API) of interest. Notably, one or more of these components/excipients may be utilized to result in a TDS with the preferred properties. The TDS includes naturally abundant polysaccharide component(s). Naturally-derived polysaccharides are a useful base component as they are generally non-toxic and non-antigenic, leading to the potential of polysaccharides to minimize irritation that can be caused by synthetic TDSs. One of the major benefit of polysaccharides is that they are easily derivatized to introduce a variety of properties that would be beneficial for TDS, including enhanced antibacterial, biocompatibility, process ability, adhesive, and film forming properties, as well as introducing ionic components to polysaccharide structure, etc.
- They are small (~1” dia.), thin, and commercially feasible from a consumer use point of view
- They are composed of inexpensive biomaterials and can be manufactured in a cost-effective manner, ensuring appreciable profit margins
- Ex vivo studies have revealed their versatility in delivering a variety of therapeutic molecules for vastly different medical Utilization of transdermal technology opens an entirely new differentiated value-add revenue stream through simple alteration of delivery mechanism
- The use of this new technology increases market share in the pediatric, elderly, and disabled populations, providing an alternative method of drug delivery over competitors; patches are clinically proven to be effective in increasing compliance, reducing side effects, increasing bioavailability, and reducing the need to re-dose medicine
- Oral medication compliance rates are consistently decreasing, and market data indicates that innovative drug delivery solutions will provide a highly profitable solution to this issue. Finished product development, about to start U.S. FDA registration（501K）